AQP8 promotes glioma proliferation and growth, possibly through the ROS/PTEN/AKT signaling pathway.

ABSTRACT:

Background

The aquaporin (AQP) family of proteins has been implicated in the proliferation and growth of gliomas. Expression of AQP8 is higher in human glioma tissues than in normal brain tissues and is positively correlated with the pathological grade of glioma, suggesting that this protein is also involved in the proliferation and growth of glioma. However, the mechanism by which AQP8 promotes the proliferation and growth of glioma remains unclear. This study aimed to investigate the mechanism and role of abnormal AQP8 expression in glioma development.

Methods

The dCas9-SAM and CRISPR/Cas9 techniques were used to construct viruses with overexpressed and knocked down AQP8, respectively, and infect A172 and U251 cell lines. The effects of AQP8 on the proliferation and growth

SUBMITTER: Hao Z 

PROVIDER: S-EPMC10242804 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature