Antitumor therapy for breast cancer: Focus on tumor-associated macrophages and nanosized drug delivery systems.

ABSTRACT:

Background

In breast cancer (BC), tumor-associated macrophages (TAMs) are an important component of the tumor microenvironment and are closely related to poor prognosis. A growing number of studies have focused on the role of TAMs in BC progression and therapeutic strategies targeting TAMs. As an emerging treatment, the application of nanosized drug delivery systems (NDDSs) in the treatment of BC by targeting TAMs has attracted much attention.

Aims

This review is to summarize the characteristics and treatment strategies targeting TAMs in BC and to clarify the applications of NDDSs targeting TAMs in the treatment of BC by targeting TAMs.

Materials & methods

The existing results related to characteristics of TAMs in BC, BC treatment strategies by targeting TAMs, and the

SUBMITTER: Zhan C 

PROVIDER: S-EPMC10242868 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature