Associations between T cells and attention problems in the general pediatric population: The Generation R study.

ABSTRACT:

Objective

The pathogenesis of attention-deficit/hyperactivity disorder (ADHD) is currently unclear. We hypothesized that chronic immune activation, as indexed by T and B cells, plays a role in the pathophysiology of attention problems. Therefore, we examined T and B cell subsets in a general pediatric population with information on attention problems.

Methods

We included 756 10-year-old children from the Generation R population-based cohort. Eleven-color flow cytometry was performed on peripheral blood samples to determine T and B cell subsets. The Child Behavior Checklist rated by parents was used to measure attention problems. Data were analyzed using linear regression analyses, adjusting for maternal and child covariates and co-occurring childhood psychopathology.

Resu

SUBMITTER: Looman KIM 

PROVIDER: S-EPMC10242894 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature