No effects of siblings and twin testosterone transfer on autistic traits.

ABSTRACT:

Background

Having twin and non-twin siblings might influence autistic traits both prenatally and postnatally. The twin testosterone transfer hypothesis suggests that girls with a twin brother are exposed to higher levels of prenatal testosterone than girls with a twin sister, and that increased testosterone exposure masculinizes neural development and increases autistic traits. Postnatally, siblings may provide example behaviour, which could reduce autistic traits.

Methods

We studied pre- and postnatal influences of twin and non-twin siblings on mother and teacher-reported autistic traits in 7714 dizygotic twins. We examined the effect of sex of the proband child and of the siblings. We fitted regression models (for boys and girls separately) with sex of co-twin and having o

SUBMITTER: de Wit MM 

PROVIDER: S-EPMC10242923 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature