Mechanical ventilation in patients with acute brain injury: a systematic review with meta-analysis.

ABSTRACT:

Objective

To describe the potential effects of ventilatory strategies on the outcome of acute brain-injured patients undergoing invasive mechanical ventilation.

Design

Systematic review with an individual data meta-analysis.

Setting

Observational and interventional (before/after) studies published up to August 22nd, 2022, were considered for inclusion. We investigated the effects of low tidal volume Vt < 8 ml/Kg of IBW versus Vt >  = 8 ml/Kg of IBW, positive end-expiratory pressure (PEEP) < or >  = 5 cmH₂O and protective ventilation (association of both) on relevant clinical outcomes.

Population

Patients with acute brain injury (trauma or haemorrhagic stroke) with invasive mechanical ventilation for ≥ 24 h.

Main outcome measures

The primary ou

SUBMITTER: Asehnoune K 

PROVIDER: S-EPMC10242967 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature