SYT7 regulates the progression of chronic lymphocytic leukemia through interacting and regulating KNTC1

ABSTRACT:

Background

Chronic lymphocytic leukemia (CLL) is one of the most frequent occurring types of leukemia. It typically occurs in elderly patients and has a highly variable clinical course. At present, the molecular mechanism driving the pathogenesis and progression of CLL is not fully understood. The protein Synaptotagmin 7 (SYT7) encoded by the SYT7 gene has been found to be closely related to the development of various solid tumors, but its role in CLL is unclear. In this study, we investigated the function and molecular mechanism of SYT7 in CLL.

Methods

The expression level of SYT7 in CLL was determined by immunohistochemical staining and qPCR. The role of SYT7 in promoting CLL development was verified by in vivo and in vitro experiments. The molecular mechanism of SYT7 i

SUBMITTER: Zhang W 

PROVIDER: S-EPMC10242988 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature