Skin absorption of felbinac solid nanoparticles in gel formulation containing l-menthol and carboxypolymethylene.

ABSTRACT:

Background

It is important to design an effective formulation to enhance the skin penetration, and nanotechnologies have been used in dermal and transdermal drug delivery. In this study, we prepared formulations (gels) containing l-menthol and felbinac (FEL) solid nanoparticles (FEL-NP gel) for topical application, and investigated the local and systemic absorption of the prepared FEL-NP gel.

Methods

FEL solid nanoparticles were obtained by bead milling of FEL powder (microparticles), and a topical formulation (FEL-NP gel) consisting of 1.5% FEL solid nanoparticles), 2% carboxypolymethylene, 2% l-menthol, 0.5% methylcellulose, and 5% 2-hydroxypropyl-β-cyclodextrin (w/w %) were prepared.

Results

The particle size of FEL nanoparticles was 20-200 nm. The released FEL con

SUBMITTER: Kadowaki R 

PROVIDER: S-EPMC10243057 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature