Detecting gene breakpoints in noisy genome sequences using position-annotated colored de-Bruijn graphs.

ABSTRACT:

Background

Identifying the locations of gene breakpoints between species of different taxonomic groups can provide useful insights into the underlying evolutionary processes. Given the exact locations of their genes, the breakpoints can be computed without much effort. However, often, existing gene annotations are erroneous, or only nucleotide sequences are available. Especially in mitochondrial genomes, high variations in gene orders are usually accompanied by a high degree of sequence inconsistencies. This makes accurately locating breakpoints in mitogenomic nucleotide sequences a challenging task.

Results

This contribution presents a novel method for detecting gene breakpoints in the nucleotide sequences of complete mitochondrial genomes, taking into account possible high

SUBMITTER: Fiedler L 

PROVIDER: S-EPMC10243065 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature