Convergence of Ras- and Rac-regulated formin pathways is pivotal for phagosome formation and particle uptake in <i>Dictyostelium</i>.

ABSTRACT: Macroendocytosis comprising phagocytosis and macropinocytosis is an actin-driven process regulated by small GTPases that depend on the dynamic reorganization of the membrane that protrudes and internalizes extracellular material by cup-shaped structures. To effectively capture, enwrap, and internalize their targets, these cups are arranged into a peripheral ring or ruffle of protruding actin sheets emerging from an actin-rich, nonprotrusive zone at its base. Despite extensive knowledge of the mechanism driving actin assembly of the branched network at the protrusive cup edge, which is initiated by the actin-related protein (Arp) 2/3 complex downstream of Rac signaling, our understanding of actin assembly in the base is still incomplete. In the Dictyostelium model system, the Ras-reg

SUBMITTER: Korber S 

PROVIDER: S-EPMC10243128 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature