Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma.

ABSTRACT: Olfactory neuroblastoma is a rare tumor arising from the olfactory cleft region of the nasal cavity. Because of the low incidence of this tumor, as well as an absence of established cell lines and murine models, understanding the mechanisms driving olfactory neuroblastoma pathobiology has been challenging. Here, we sought to apply advances from research on the human olfactory epithelial neurogenic niche, along with new biocomputational approaches, to better understand the cellular and molecular factors in low- and high-grade olfactory neuroblastoma and how specific transcriptomic markers may predict prognosis. We analyzed a total of 19 olfactory neuroblastoma samples with available bulk RNA-sequencing and survival data, along with 10 samples from normal olfactory epithelium. A bulk RNA-seq

SUBMITTER: Finlay JB 

PROVIDER: S-EPMC10243222 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature