Stress-induced biological aging: A review and guide for research priorities.

ABSTRACT: Exposure to chronic adverse conditions, and the resultant activation of the neurobiological response cascade, has been associated with an increased risk of early onset of age-related disease and, recently, with an older biological age. This body of research has led to the hypothesis that exposure to stressful life experiences, when occurring repeatedly or over a prolonged period, may accelerate the rate at which the body ages. The mechanisms through which chronic psychosocial stress influences distinct biological aging pathways to alter rates of aging likely involve multiple layers in the physiological-molecular network. In this review, we integrate research using animal, human, and in vitro models to begin to delineate the distinct pathways through which chronic psychosocial stress may im

SUBMITTER: Polsky LR 

PROVIDER: S-EPMC10243290 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature