Genomic profiling of ovarian clear cell carcinoma in Chinese patients reveals potential prognostic biomarkers for survival.

ABSTRACT:

Introduction

Ovarian clear cell carcinoma (OCCC) has distinct clinical and molecular features and heterogeneous prognosis. Insights into the somatic genomic abnormalities of OCCC provide the basis for deeper understanding and potential therapeutic avenues. Herein, we performed extensive genomic profiling in Chinese patients to illustrate the mutation landscape and genetic prognostic biomarkers of OCCC.

Patients and methods

We used targeted DNA sequencing on 61 OCCC cases with a panel of 520 cancer-related genes. Correlations between clinicopathological features and survival were evaluated. Nomogram-based models were constructed to predict progress-free survival (PFS).

Results

We detected 763 somatic mutations spanning 286 genes. The most frequent genetic alterations,

SUBMITTER: Ye S 

PROVIDER: S-EPMC10243386 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature