Genetic analysis of infectious bronchitis virus (IBV) in vaccinated poultry populations over a period of 10 years.

ABSTRACT: Infectious bronchitis virus (IBV) is an avian pathogen from the Coronavirus family causing major health issues in poultry flocks worldwide. Because of its negative impact on health, performance, and bird welfare, commercial poultry are routinely vaccinated by administering live attenuated virus. However, field strains are capable of rapid adaptation and may evade vaccine-induced immunity. We set out to describe dynamics within and between lineages and assess potential escape from vaccine-induced immunity. We investigated a large nucleotide sequence database of over 1700 partial sequences of the S1 spike protein gene collected from clinical samples of Dutch chickens submitted to the laboratory of Royal GD between 2011 and 2020. Relative frequencies of the two major lineages GI-13 (793B) and

SUBMITTER: Vermeulen CJ 

PROVIDER: S-EPMC10243407 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature