Transvalvular Ventricular Unloading Before Reperfusion in Acute Myocardial Infarction.

ABSTRACT:

Background

Myocardial damage due to acute ST-segment elevation myocardial infarction (STEMI) remains a significant global health problem. New approaches to limit myocardial infarct size and reduce progression to heart failure after STEMI are needed. Mechanically reducing left ventricular (LV) workload (LV unloading) before coronary reperfusion is emerging as a potential approach to reduce infarct size.

Objectives

Given the central importance of mitochondria in reperfusion injury, we hypothesized that compared with immediate reperfusion (IR), LV unloading before reperfusion improves myocardial energy substrate use and preserves mitochondrial structure and function.

Methods

To explore the effect of LV unloading duration on infarct size, we analyzed data from the STEMI-D

SUBMITTER: Swain L 

PROVIDER: S-EPMC10243472 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature