An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells.

ABSTRACT: Immunoglobulin A (IgA) secretion by plasma cells, terminally differentiated B cells residing in the intestinal lamina propria, assures microbiome homeostasis and protects the host against enteric infections. Exposure to diet-derived and commensal-derived signals provides immune cells with organizing cues that instruct their effector function and dynamically shape intestinal immune responses at the mucosal barrier. Recent data have described metabolic and microbial inputs controlling T cell and innate lymphoid cell activation in the gut; however, whether IgA-secreting lamina propria plasma cells are tuned by local stimuli is completely unknown. Although antibody secretion is considered to be imprinted during B cell differentiation and therefore largely unaffected by environmental changes, a

SUBMITTER: Ceglia S 

PROVIDER: S-EPMC10243503 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature