Association of Polymorphisms in ZFHX1B and PAX6 With Anisometropia in Chinese Children: The Hong Kong Children Eye Genetics Study.

ABSTRACT:

Purpose

To identify gene variants associated with anisometropia development in children.

Methods

This is a population-based, cross-sectional, and longitudinal genetic association study involving 1057 children aged 6 to 10 years with both baseline and 3-year follow-up data. Six single nucleotide polymorphisms (SNPs), ZC3H11B rs4373767, ZFHX1B rs13382811, KCNQ5 rs7744813, SNTB1 rs7839488, PAX6 rs644242, and GJD2 rs524952 were analyzed in all children. Anisometropia was defined by an interocular difference in SE of ≥1 diopter (D) (Aniso-SE) and an interocular difference in axial length (AL) of ≥0.3 mm (Aniso-AL), respectively. Genetic associations of individual SNPs and joint SNP effects were analyzed.

Results

ZFHX1B rs13382811 was associated nominally with Aniso-AL (odd

SUBMITTER: Wang YY 

PROVIDER: S-EPMC10243505 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature