Maternal smoking, genetic susceptibility, and birth-to-adulthood body weight.

ABSTRACT:

Background

Maternal smoking (MS) is associated with low birthweight (BW) but adult obesity in offspring, however, it remains unknown whether it modifies offspring's genetic susceptibility to obesity on BW, adult body weight, and birth-to-adulthood body weight tracking pattern.

Methods

This study included 246,759 UK Biobank participants with information on MS, BW (kg), adult body weight and BMI (kg/m²). Individual polygenetic score (PGS) was created on the basis of 97 BMI-associated genetic loci. We calculated individual birth-to-adulthood percentile change, and body weight tracking patterns that combined BW levels (<2.5, 2.5-4.0, and ≥4.0 as low, normal and high BW [LBW, NBW, and HBW]) and adulthood obesity status (≥30 as obesity [OB] and <30 as non-obesity [NOB])

SUBMITTER: Sun D 

PROVIDER: S-EPMC10243517 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature