Establishment and validation of a ferroptosis-related signature predicting prognosis and immunotherapy effect in colon cancer.

ABSTRACT:

Background

Ferroptosis, a novel form of regulating cell death, is related to various cancers. However, the role of ferroptosis-related genes (FRGs) on the occurrence and development of colon cancer (CC) needs to be further elucidated.

Method

CC transcriptomic and clinical data were downloaded from TCGA and GEO databases. The FRGs were obtained from the FerrDb database. The consensus clustering was performed to identify the best clusters. Then, the entire cohort was randomly divided into the training and testing cohorts. Univariate Cox, LASSO regression and multivariate Cox analyses were used to construct a novel risk model in training cohort. The testing and the merged cohorts were performed to validate the model. Moreover, CIBERSORT algorithm analyze TIME between high- and

SUBMITTER: Li Z 

PROVIDER: S-EPMC10243598 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature