Morphological and molecular comparison of HIV-associated and sporadic inclusion body myositis.

ABSTRACT:

Objective

The molecular characteristics of sporadic inclusion body myositis (sIBM) have been intensively studied, and specific patterns on the cellular, protein and RNA level have emerged. However, these characteristics have not been studied in the context of HIV-associated IBM (HIV-IBM). In this study, we compared clinical, histopathological, and transcriptomic patterns of sIBM and HIV-IBM.

Methods

In this cross-sectional study, we compared patients with HIV-IBM and sIBM based on clinical and morphological features as well as gene expression levels of specific T-cell markers in skeletal muscle biopsy samples. Non-disease individuals served as controls (NDC). Cell counts for immunohistochemistry and gene expression profiles for quantitative PCR were used as primary outcomes.

SUBMITTER: Vogt S 

PROVIDER: S-EPMC10243696 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature