A High Frequency of Chromosomal Duplications in Unicellular Algae Is Compensated by Translational Regulation.

ABSTRACT: Although duplications have long been recognized as a fundamental process driving major evolutionary innovations, direct estimates of spontaneous chromosome duplication rates, leading to aneuploid karyotypes, are scarce. Here, from mutation accumulation (MA) experiments, we provide the first estimates of spontaneous chromosome duplication rates in six unicellular eukaryotic species, which range from 1 × 10-4 to 1 × 10-3 per genome per generation. Although this is ∼5 to ∼60 times less frequent than spontaneous point mutations per genome, chromosome duplication events can affect 1-7% of the total genome size. In duplicated chromosomes, mRNA levels reflected gene copy numbers, but the level of translation estimated by polysome profiling revealed that dosage compensation must be occurring. In p

SUBMITTER: Krasovec M 

PROVIDER: S-EPMC10243874 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature