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Within-Host Evolution of SARS-CoV-2 in a B-Cell Depleted Patient With Successful Treatment.

ABSTRACT: Prolonged viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an immunocompromised host is a challenge as the treatment and infection control for chronic coronavirus disease 2019 infection is not well established and there is a potential risk of new variants emerging. A 48-year-old woman who underwent chemotherapy, including rituximab and steroid, had reactivation of SARS-CoV-2 68 days after the virus was first detected. She successfully recovered after receiving convalescent plasma and intravenous immunoglobulin. Genomic analysis demonstrated that viruses collected from the nasopharyngeal specimens at day 0 and day 68 had 18 different nucleotide mutations, implying within-host evolution after in-depth epidemiologic investigation.

SUBMITTER: Baek YJ

PROVIDER: S-EPMC10244020 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Within-Host Evolution of SARS-CoV-2 in a B-Cell Depleted Patient With Successful Treatment.

Baek Yae Jee YJ Park Gemma G Choi Jun Yong JY Kim Eun Jin EJ Kim Bryan Inho BI Gwack Jin J Jung Ji Ye JY

Journal of Korean medical science 20230605 22

Prolonged viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an immunocompromised host is a challenge as the treatment and infection control for chronic coronavirus disease 2019 infection is not well established and there is a potential risk of new variants emerging. A 48-year-old woman who underwent chemotherapy, including rituximab and steroid, had reactivation of SARS-CoV-2 68 days after the virus was first detected. She successfully recovered after receiving co ...[more]

PMID: 37272563

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