Lifestyle, genetic risk and incidence of cancer: a prospective cohort study of 13 cancer types.

ABSTRACT:

Background

Genetic and lifestyle factors are associated with cancer risk. We investigated the benefits of adhering to lifestyle advice by the World Cancer Research Fund (WCRF) with the risk of 13 types of cancer and whether these associations differ according to genetic risk using data from the UK Biobank.

Methods

In 2006-2010, participants aged 37-73 years had their lifestyle assessed and were followed up for incident cancers until 2015-2019. Analyses were restricted to those of White European ancestry with no prior history of malignant cancer (n = 195 822). Polygenic risk scores (PRSs) were computed for 13 cancer types and these cancers combined ('overall cancer'), and a lifestyle index was calculated from WCRF recommendations. Associations with cancer incidence were estim

SUBMITTER: Byrne S 

PROVIDER: S-EPMC10244040 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature