Linc00662 m⁶A promotes the progression and metastasis of pancreatic cancer by activating focal adhesion through the GTF2B-ITGA1-FAK pathway.

ABSTRACT: Recurrence and metastasis are major factors associated with the poor prognosis of pancreatic cancer (PC). Previous studies have indicated that METTL3-mediated N6-methyladenosine (m⁶A) modification is closely associated with PC progression and prognosis. However, its underlying regulatory mechanisms remain unclear. In this study, we found that METTL3 was upregulated in PC tissues and cells and was associated with malignant tumor progression and poor progression-free survival in PC. Linc00662 was screened as a m⁶A-enriched RNA that promoted tumor growth and metastasis in PC cells and mouse models and was associated with poor clinical prognosis. Four m⁶A motifs were identified in Linc00662, which maintained the stability of Linc00662 in an IGF2BP3-coupled mann

SUBMITTER: Zhang S 

PROVIDER: S-EPMC10244093 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature