Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC10244117 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Xu Yanming Y Li Ying Y Yang Xiaodong X Lu Dehua D Zheng Yuanyuan Y Tan Jingyun J Li Wenhua W Chen Qi Q Liu Yajie Y Gao Jing J Wang Shubin S
American journal of cancer research 20230515 5
Studies have demonstrated that the tumour microenvironment is hypoxia and that hypoxia can induce hypoxia inducible factor-1α (HIF-1α) expression and mediate tumour chemoresistance, which leads to a very poor prognosis for cancer patients. In this study, an economical and practical HIF-1α inhibitor, plasma-activated medium (PAM), was prepared, and its role in colorectal cancer (CRC) was investigated <i>in vitro</i> and <i>in vivo</i>. We found that HIF-1α expression significantly increased under ...[more]