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Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases.

ABSTRACT: Mitochondria are complex metabolic organelles with manifold pathophysiological implications in diabetes. Currently published mitochondrial-encoded peptides, which are expressed from the mitochondrial open reading frame of the 12S ribosomal RNA type-c (MOTS-c), 16S rRNA (humanin and short humanin like peptide 1-6 [SHLP1-6]), or small human mitochondrial open reading frame over serine tRNA (SHMOOSE) are associated with regulation of cellular metabolism and insulin action in age-related diseases, such as type 2 diabetes mellitus. This review focuses mainly on recent advances in MOTS-c research with regards to diabetes, including both type 1 and type 2. The emerging understanding of MOTS-c in diabetes may provide insight into the development of new therapies for diabetes and other age or senescence-related diseases.

SUBMITTER: Kong BS

PROVIDER: S-EPMC10244198 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases.

Kong Byung Soo BS Lee Changhan C Cho Young Min YM

Diabetes & metabolism journal 20230224 3

Mitochondria are complex metabolic organelles with manifold pathophysiological implications in diabetes. Currently published mitochondrial-encoded peptides, which are expressed from the mitochondrial open reading frame of the 12S ribosomal RNA type-c (MOTS-c), 16S rRNA (humanin and short humanin like peptide 1-6 [SHLP1-6]), or small human mitochondrial open reading frame over serine tRNA (SHMOOSE) are associated with regulation of cellular metabolism and insulin action in age-related diseases, s ...[more]

PMID: 36824008

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