RaPID-Query for Fast Identity by Descent Search and Genealogical Analysis.

ABSTRACT:

Motivation

Due to the rapid growth of the genetic database size, genealogical search, a process of inferring familial relatedness by identifying DNA matches, has become a viable approach to help individuals finding missing family members or law enforcement agencies locating suspects. A fast and accurate method is needed to search an out-of-database individual against millions of individuals. Most existing approaches only offer all-vs-all within panel match. Some prototype algorithms offer one-vs-all query from out-of-panel individual, but they do not tolerate errors.

Results

A new method, random projection-based identical-by-descent (IBD) detection (RaPID) query, is introduced to make fast genealogical search possible. RaPID-Query identifies IBD segments between a query hapl

SUBMITTER: Wei Y 

PROVIDER: S-EPMC10244210 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature