Cross-cancer pleiotropic analysis identifies three novel genetic risk loci for colorectal cancer.

ABSTRACT:

Background

To understand the shared genetic basis between colorectal cancer (CRC) and other cancers and identify potential pleiotropic loci for compensating the missing genetic heritability of CRC.

Methods

We conducted a systematic genome-wide pleiotropy scan to appraise associations between cancer-related genetic variants and CRC risk among European populations. Single nucleotide polymorphism (SNP)-set analysis was performed using data from the UK Biobank and the Study of Colorectal Cancer in Scotland (10 039 CRC cases and 30 277 controls) to evaluate the overlapped genetic regions for susceptibility of CRC and other cancers. The variant-level pleiotropic associations between CRC and other cancers were examined by CRC genome-wide association study meta-analysis and the plei

SUBMITTER: Sun J 

PROVIDER: S-EPMC10244225 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature