Phase holograms for the three-dimensional patterning of unconstrained microparticles.

ABSTRACT: Acoustic radiation forces can remotely manipulate particles. Forces from a standing wave field align microscale particles along the nodal or anti-nodal locations of the field to form three-dimensional (3D) patterns. These patterns can be used to form 3D microstructures for tissue engineering applications. However, standing wave generation requires more than one transducer or a reflector, which is challenging to implement in vivo. Here, a method is developed and validated to manipulate microspheres using a travelling wave from a single transducer. Diffraction theory and an iterative angular spectrum approach are employed to design phase holograms to shape the acoustic field. The field replicates a standing wave and aligns polyethylene microspheres in water, which are analogous to cells in v

SUBMITTER: Ghanem MA 

PROVIDER: S-EPMC10244404 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature