Biomarkers of central and peripheral inflammation mediate the association between HIV and depressive symptoms.

ABSTRACT: People living with HIV are at increased risk for depression, though the underlying mechanisms for this are unclear. In the general population, depression is associated with peripheral and central inflammation. Given this, and since HIV infection elicits inflammation, we hypothesised that peripheral and central inflammatory biomarkers would at least partly mediate the association between HIV and depressive symptoms. People living with HIV (n = 125) and without HIV (n = 79) from the COmorBidity in Relation to AIDS (COBRA) cohort were included in this study. Participants living with and without HIV had similar baseline characteristics. All participants living with HIV were on antiretroviral therapy and were virally suppressed. Plasma, CSF, and brain MR spectroscopy (MRS) biomarkers were measu

SUBMITTER: Mudra Rakshasa-Loots A 

PROVIDER: S-EPMC10244452 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature