CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation.

ABSTRACT: CD4⁺ T helper (Th) cell differentiation is regulated by lineage-specific expression of transcription factors, which is tightly associated with epigenetic modifications, including histone acetylation and methylation. However, the factors regulating histone modifications involved in Th cell differentiation remain largely unknown. We herein demonstrated a critical role of Cullin 4B (CUL4B) in restricting Th1 and Th2 cell differentiation. CUL4B, which is assembled into the CUL4B-RING E3 ligase (CRL4B) complex, participates in various physiological and developmental processes through epigenetic repression of transcription. Depletion of Cul4b in CD4⁺ T cells enhanced Th1 and Th2 cell differentiation. In vivo, an aggravated Th2 response caused by the absence of CUL4B was obs

SUBMITTER: Qin L 

PROVIDER: S-EPMC10244459 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature