Validity of CSF alpha-synuclein to predict psychosis in prodromal Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) accompanied by psychotic symptoms (PS) has a poor prognosis and may be associated with imbalances in key neural proteins such as alpha-synuclein (AS).

Aim

The aim of the study was to evaluate the diagnostic validity of AS levels in the cerebrospinal fluid (CSF) as a predictor of the emergence of PS in patients with prodromal AD.

Materials and methods

Patients with mild cognitive impairment were recruited between 2010 and 2018. Core AD biomarkers and AS levels were measured in CSF obtained during the prodromal phase of the illness. All patients who met the NIA-AA 2018 criteria for AD biomarkers received treatment with anticholinesterasic drugs. Follow-up evaluations were conducted to assess patients for the presence of psychosis usin

SUBMITTER: Monge-Garcia S 

PROVIDER: S-EPMC10244520 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature