The role of dietary magnesium deficiency in inflammatory hypertension.

ABSTRACT: Nearly 30% of adults consume less than the estimated average daily requirement of magnesium (Mg²⁺), and commonly used medications, such as diuretics, promote Mg²⁺ deficiency. Higher serum Mg²⁺ levels, increased dietary Mg²⁺ in-take, and Mg²⁺ supplementation are each associated with lower blood pressure, suggesting that Mg²⁺-deficiency contributes to the pathogenesis of hypertension. Antigen-presenting cells, such as monocytes and dendritic cells, are well-known to be involved in the pathogenesis of hypertension. In these cells, processes implicated as necessary for increased blood pressure include activation of the NLRP3 inflammasome, IL-1β production, and oxidative modification of fatty acids such as arachidonic acid, formi

SUBMITTER: Pitzer Mutchler A 

PROVIDER: S-EPMC10244581 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature