Genetic control of N-glycosylation of human blood plasma proteins.

ABSTRACT: Glycosylation is an important protein modification, which influences the physical and chemical properties as well as biological function of these proteins. Large-scale population studies have shown that the levels of various plasma protein N-glycans are associated with many multifactorial human diseases. Observed associations between protein glycosylation levels and human diseases have led to the conclusion that N-glycans can be considered a potential source of biomarkers and therapeutic targets. Although biochemical pathways of glycosylation are well studied, the understanding of the mechanisms underlying general and tissue-specific regulation of these biochemical reactions in vivo is limited. This complicates both the interpretation of the observed associations between protein glycosylat

SUBMITTER: Sharapov SZ 

PROVIDER: S-EPMC10244589 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature