The relationship between gut microbiota and inflammatory response, learning and memory in mice by sleep deprivation.

ABSTRACT:

Objective

Sleep deprivation has developed into a common phenomenon, which can lead to inflammatory responses and cognitive impairment, but the underlying mechanism is ambiguous. Emerging evidence shows that gut microbiota plays a crucial role in theoccurrence and development of inflammatory and psychiatric diseases, possibly through neuroinflammation and the brain-gut axis. The current study investigated the influence of sleep deprivation on gut microbiota composition, pro-inflammatory cytokines, learning and memory in mice. Further, it explored whether changes in gut microbiota increase pro-inflammatory cytokine and induce learning and memory impairment.

Methods

Healthy 8-week-old male C57BL/6J mice were randomly divided into the regular control group (RC), environmental co

SUBMITTER: Zhang M 

PROVIDER: S-EPMC10244646 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature