Human complement component C3 N-glycome changes in type 1 diabetes complications.

ABSTRACT:

Aim

Changes in N-glycosylation have been described in numerous diseases and are being considered as biomarkers of ongoing pathological condition. Previous studies demonstrated the interrelation of N-glycosylation and type 1 diabetes (T1D), particularly linking serum N-glycan changes with complications accompanying the disease. Moreover, the role of complement component C3 in diabetic nephropathy and retinopathy has been implicated, and C3 N-glycome was found to be altered in young T1D patients. Therefore, we investigated associations between C3 N-glycan profiles and albuminuria and retinopathy accompanying T1D, as well as glycosylation connection with other known T1D complication risk factors.

Research design and methods

Complement component C3 N-glycosylation profiles have

SUBMITTER: Soic D 

PROVIDER: S-EPMC10244649 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature