Ovalbumin-specific CD4⁺ and CD8⁺ T cells contribute to different susceptibility for Theiler's murine encephalomyelitis virus persistence.

ABSTRACT: Theiler's murine encephalomyelitis virus (TMEV) is the causative agent of TMEV-induced demyelinating disease (TMEV-IDD); a well-established animal model for the chronic progressive form of human multiple sclerosis (MS). In susceptible mice with an inadequate immune response, TMEV-IDD is triggered by virus persistence and maintained by a T cell mediated immunopathology. OT-mice are bred on a TMEV-resistant C57BL/6 background and own predominantly chicken ovalbumin (OVA)-specific populations of CD8⁺ T cells (OT-I) or CD4⁺ T cells (OT-II), respectively. It is hypothesized that the lack of antigen specific T cell populations increases susceptibility for a TMEV-infection in OT-mice on a TMEV-resistant C57BL/6 background. OT-I, OT-II, and C57BL/6 control mice were infected

SUBMITTER: Wannemacher R 

PROVIDER: S-EPMC10244668 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature