In vivo¹⁸F-DOPA PET imaging identifies a dopaminergic deficit in a rat model with a G51D α-synuclein mutation.

ABSTRACT: Parkinson's disease (PD) is a neurodegenerative condition with several major hallmarks, including loss of substantia nigra neurons, reduction in striatal dopaminergic function, and formation of α-synuclein-rich Lewy bodies. Mutations in SNCA, encoding for α-synuclein, are a known cause of familial PD, and the G51D mutation causes a particularly aggressive form of the condition. CRISPR/Cas9 technology was used to introduce the G51D mutation into the endogenous rat SNCA gene. SNCA^G51D/+ and SNCA^G51D/G51D rats were born in Mendelian ratios and did not exhibit any severe behavourial defects. L-3,4-dihydroxy-6-¹⁸F-fluorophenylalanine (¹⁸F-DOPA) positron emission tomography (PET) imaging was used to investigate

SUBMITTER: Morley V 

PROVIDER: S-EPMC10244711 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature