Gene expression changes in cerebellum induced by dietary restriction.

ABSTRACT:

Background

Dietary restriction (DR) is a well-established universal anti-aging intervention, and is neuroprotective in multiple models of nervous system disease, including models with cerebellar pathology. The beneficial effects of DR are associated with a rearrangement of gene expression that modulate metabolic and cytoprotective pathways. However, the effect of DR on the cerebellar transcriptome remained to be fully defined.

Results

Here we analyzed the effect of a classical 30% DR protocol on the transcriptome of cerebellar cortex of young-adult male mice using RNAseq. We found that about 5% of expressed genes were differentially expressed in DR cerebellum, the far majority of whom showing subtle expression changes. A large proportion of down-regulated genes are implicate

SUBMITTER: Van't Sant LJ 

PROVIDER: S-EPMC10244750 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature