Measles, mumps, and rubella vaccine at age 6 months and hospitalisation for infection before age 12 months: randomised controlled trial.

ABSTRACT:

Objective

To test for potential non-specific effects of an additional, early measles, mumps, and rubella (MMR) vaccine at age 5-7 months on risk of infection related hospitalisation before age 12 months.

Design

Randomised, double blinded, placebo controlled trial.

Setting

Denmark, a high income setting with low exposure to MMR.

Participants

6540 Danish infants aged 5 to 7 months.

Interventions

Infants were randomly allocated 1:1 to intramuscular injection with standard titre MMR vaccine (M-M-R VaxPro) or placebo (solvent only).

Main outcome measures

Hospitalisations for infection, defined as all hospital contacts of infants referred from primary care for hospital evaluation and with an infection diagnosed, analysed as recurrent events, from random

SUBMITTER: Zimakoff AC 

PROVIDER: S-EPMC10245144 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature