Arctigenin hinders the invasion and metastasis of cervical cancer cells via the FAK/paxillin pathway.

ABSTRACT:

Context

Cervical cancer is the most common gynecological pernicious tumor with high morbidity and mortality worldwide, especially in developing countries. Arctigenin (ARG), a nature-derived component, has exhibited anti-tumor activity in various tumors.

Objective

To explore the effect of ARG on cervical cancer.

Materials and methods

The effect and mechanism of ARG on cervical cancer cells were explored by cell counting kit-8 (CCK-8), flow cytometry, transwell and Western blot assays. Additionally, in vivo experiment was conducted in xenografted mice by immunohistochemistry (IHC), terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL) and Western blot assays.

Results

ARG treatment induced both concentration-depend

SUBMITTER: Liao D 

PROVIDER: S-EPMC10245248 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature