<i>In vivo</i> antidiarrheal activity of the crude extract and solvent fractions of <i>Rhamnus prinoides</i> (Rhamnaceae) leaves.

ABSTRACT:

Background

Even though numerous conventional anti-diarrheal agents are available, the inherent toxicities of the drugs urge the search for alternative drugs that are safe and effective.

Objective

To evaluate the in-vivo anti-diarrheal activity of crude extract and solvent fractions of Rhamnus prinoides leaves.

Materials and methods

The Rhamnus prinoides leaves were macerated using absolute methanol and then fractionated using solvents of different polarity indexes. For in-vivo antidiarrheal activity evaluation of the crude extract and solvent fraction, castor oil-induced diarrhea, castor oil-induced anti-enteropolling, and intestinal transit models were used. One-way analysis of variance was used to analyze the data, followed by a Tukey pos

SUBMITTER: Ayele TM 

PROVIDER: S-EPMC10245265 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature