Peroxisome Proliferator-Activated Receptor α and γ Gene Polymorphisms among South Indian Patients with Diabetic Dyslipidaemia.

ABSTRACT:

Background

Peroxisome proliferator-activated receptors (PPAR) α and γ genes play an important role in dyslipidaemia of T2DM.

Aims

To estimate the frequency distribution of PPAR α and γ gene polymorphisms in South Indian T2DM patients with dyslipidaemia compared to healthy controls. Normative frequencies of SNPs were established and compared with data for 1000 genome populations.

Methods

Eligible 382 cases and 336 age and sex-matched controls were enrolled. Six SNPs in PPARα [rs1800206 C>G (Leu162Val), rs4253778 G>C, rs135542 T>C] and PPARγ [rs3856806 (C>T), rs10865710 (C>G), rs1805192 C>G (Pro12Ala)] genes were selected for genotyping.

Results

The allele and gene frequencies did not significantly differ between the diabetic dyslipidaemia cases and healthy contr

SUBMITTER: Bage IJ 

PROVIDER: S-EPMC10245317 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature