Circulating sepsis-related metabolite sphinganine could protect against intestinal damage during sepsis.

ABSTRACT:

Introduction

Sepsis is intricately linked to intestinal damage and barrier dysfunction. At present times, there is a growing interest in a metabolite-based therapy for multiple diseases.

Methods

Serum samples from septic patients and healthy individuals were collected and their metabonomics profiling assessed using Ultra-Performance Liquid Chromatography-Time of Flight Mass Spectrometry (UPLC-TOFMS). The eXtreme Gradient Boosting algorithms (XGBOOST) method was used to screen essential metabolites associated with sepsis, and five machine learning models, including Logistic Regression, XGBoost, GaussianNB(GNB), upport vector machines(SVM) and RandomForest were constructed to distinguish sepsis including a training set (75%) and validation set(25%). The area under the receiver

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10245321 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature