Effects of Local Anesthetics on Liposomal Membranes Determined by Their Inhibitory Activity of Lipid Peroxidation.

ABSTRACT: In this study, we investigated the effects of drugs on membrane function in which lipid peroxidation was inhibited by the antioxidant Trolox (TRO) in liposomes containing egg yolk lecithin. Local anesthetics (LAs), such as lidocaine (LID) and dibucaine (DIB), were used as model drugs. The effect of LAs on the inhibitory activity of TRO was evaluated by calculating the pI₅₀ from the inhibition constant K calculated by curve fitting. pI₅₀^TRO indicates the strength of TRO membrane protective function. pI₅₀^LA indicates the strength of LA activity. LAs inhibited lipid peroxidation in a dose-dependent manner and decreased pI₅₀^TRO. The effect of DIB on pI₅₀^TRO

SUBMITTER: Horizumi Y 

PROVIDER: S-EPMC10245376 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature