Laboratory-wide association study of survival with prostate cancer.

ABSTRACT:

Background

Estimates of overall patient health are essential to inform treatment decisions for patients diagnosed with cancer. The authors applied XWAS methods, herein referred to as "laboratory-wide association study (LWAS)", to evaluate associations between routinely collected laboratory tests and survival in veterans with prostate cancer.

Methods

The authors identified 133,878 patients who were diagnosed with prostate cancer between 2000 and 2013 in the Veterans Health Administration using any laboratory tests collected within 6 months of diagnosis (3,345,083 results). Using the LWAS framework, the false-discovery rate was used to test the association between multiple laboratory tests and survival, and these results were validated using training, testing, and validation c

SUBMITTER: Sohlberg EM 

PROVIDER: S-EPMC10245385 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature