H₂O₂/O₂ self-supply and Ca²⁺ overloading MOF-based nanoplatform for cascade-amplified chemodynamic and photodynamic therapy.

ABSTRACT: Introduction: Reactive oxygen species (ROS)-mediated therapies have typically been considered as noninvasive tumor treatments owing to their high selectivity and efficiency. However, the harsh tumor microenvironment severely impairs their efficiency. Methods: Herein, the biodegradable Cu-doped zeolitic imidazolate framework-8 (ZIF-8) was synthesized for loading photosensitizer Chlorin e6 (Ce6) and CaO₂ nanoparticles, followed by surface decoration by hyaluronic acid (HA), obtaining HA/CaO₂-Ce6@Cu-ZIF nano platform. Results and Discussion: Once HA/CaO₂-Ce6@Cu-ZIF targets tumor sites, the degradation of Ce6 and CaO₂ release from the HA/CaO₂-Ce6@Cu-ZIF in response to the acid environment, while the Cu²⁺ act

SUBMITTER: Liang Y 

PROVIDER: S-EPMC10245387 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature