Upper brainstem cholinergic neurons project to ascending and descending circuits.

ABSTRACT:

Background

Based on their anatomical location, rostral projections of nuclei are classified as ascending circuits, while caudal projections are classified as descending circuits. Upper brainstem neurons participate in complex information processing and specific sub-populations preferentially project to participating ascending or descending circuits. Cholinergic neurons in the upper brainstem have extensive collateralizations in both ascending and descending circuits; however, their single-cell projection patterns remain unclear because of the lack of comprehensive characterization of individual neurons.

Results

By combining fluorescent micro-optical sectional tomography with sparse labeling, we acquired a high-resolution whole-brain dataset of pontine-tegmental cholinergic n

SUBMITTER: Zhao P 

PROVIDER: S-EPMC10245412 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature