Type 2 diabetes has a protective causal association with thoracic aortic aneurysm: a Mendelian randomization study.

ABSTRACT:

Background

Observational studies have reported an inverse association of type 2 diabetes (T2D) with thoracic aortic aneurysm (TAA). However, the causality of the association has not been established yet. The present study aims to clarify the causal relationship between T2D and TAA via a Mendelian randomization (MR) approach.

Methods

Causality of associations were assessed using a two-sample MR framework. Genome-wide association study (GWAS) summary statistics were obtained for T2D, glycated hemoglobin (HbA1c), fasting glucose (FG) and fasting insulin (FI) as exposures, and TAA, ascending aortic diameter (AAoD) and descending aortic diameter (DAoD) as outcomes. Four different methods (inverse variance weighted [IVW], weight median, MR-Egger and MR-PRESSO) were used to calcula

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10245418 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature