Metal-Free Photochemical Imino-Alkylation of Alkenes with Bifunctional Oxime Esters.

ABSTRACT: The concurrent installation of C-C and C-N bonds across alkene frameworks represents a powerful tool to prepare motifs that are ubiquitous in pharmaceuticals and bioactive compounds. To construct such prevalent bonds, most alkene difunctionalization methods demand the use of precious metals or activated alkenes. We report a metal-free, photochemically mediated imino-alkylation of electronically diverse alkenes to install both alkyl and iminyl groups in a highly efficient manner. The exceptionally mild reaction conditions, broad substrate scope, excellent functional group tolerance, and facile one-pot reaction protocol highlight the utility of this method to prepare privileged motifs from readily available alkene and acid feedstocks. One key and striking feature of this transformation is th

SUBMITTER: Majhi J 

PROVIDER: S-EPMC10245625 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature