Senescent cells and macrophages cooperate through a multi-kinase signaling network to promote intestinal transformation in Drosophila.

ABSTRACT: Cellular senescence is a conserved biological process essential for embryonic development, tissue remodeling, repair, and a key regulator of aging. Senescence also plays a crucial role in cancer, though this role can be tumor-suppressive or tumor-promoting, depending on the genetic context and the microenvironment. The highly heterogeneous, dynamic, and context-dependent nature of senescence-associated features and the relatively small numbers of senescent cells in tissues makes in vivo mechanistic studies of senescence challenging. As a result, which senescence-associated features are observed in which disease contexts and how they contribute to disease phenotypes remain largely unknown. Similarly, the specific mechanisms by which various senescence-inducing signals are integrated

SUBMITTER: Datta I 

PROVIDER: S-EPMC10245684 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature